Solvent swap or solvent exchange Solvents are used in many Active Pharmaceutical Ingredients (APIs) manufacturing processes. They enable the desired chemical reaction, and solvents are also used during separation and purification steps. Download our application note and learn how, by utilizing real-time concentration measurements by Vaisala Polaris™ Refractometer, pharmaceutical manufacturers can: Determine the point for solvent swap addition Control concentration in real time during solvent swap operations Obtain process profiles for process validation, troubleshooting and optimization Optimize solvent consumption while keeping the total separation rate stable Minimize energy consumption during operation Gain process understanding on vapor-liquid equilibrium (VLE) to help to scale-up the process The application note explains in detail the benefits of using refractive index measurement technique. The note also includes recommended installation points for best performance, and shortly introduces the reliable technology our pharma refractometer is based on. Download the application note (PDF) by filling the form. Discover all applications in Pharmaceutical drug manufacturing and biotechnology processes. 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Solvents are used in many Active Pharmaceutical Ingredients (APIs) manufacturing processes. They enable the desired chemical reaction, and solvents are also used during separation and purification steps. Download our application note and learn how, by utilizing real-time concentration measurements by Vaisala Polaris™ Refractometer, pharmaceutical manufacturers can: Determine the point for solvent swap addition Control concentration in real time during solvent swap operations Obtain process profiles for process validation, troubleshooting and optimization Optimize solvent consumption while keeping the total separation rate stable Minimize energy consumption during operation Gain process understanding on vapor-liquid equilibrium (VLE) to help to scale-up the process The application note explains in detail the benefits of using refractive index measurement technique. The note also includes recommended installation points for best performance, and shortly introduces the reliable technology our pharma refractometer is based on. Download the application note (PDF) by filling the form. Discover all applications in Pharmaceutical drug manufacturing and biotechnology processes. Image Email Address*First Name*Last Name*My application (process/ liquid)Country*--Please Select--United StatesUnited KingdomCanadaChinaIndiaJapanAustraliaBrazilFranceGermanyFinland--------------AfghanistanÅland IslandsAlbaniaAlgeriaAmerican SamoaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBoliviaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBrit/Indian Ocean Terr.Brunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Dem. Republic OfCook IslandsCosta RicaCôte D'IvoireCroatiaCubaCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland IslandsFaroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern Terr.GabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuamGuatemalaGuineaGuinea-BissauGuyanaHaitiHeard/McDonald Isls.HondurasHong KongHungaryIcelandIndiaIndonesiaIranIraqIrelandIsraelItalyJamaicaJapanJordanKazakhstanKenyaKiribatiKorea (North)Korea (South)KuwaitKyrgyzstanLaosLatviaLebanonLesothoLiberiaLibyaLiechtensteinLithuaniaLuxembourgMacauMacedoniaMadagascarMalawiMalaysiaMaldivesMaliMaltaMarshall IslandsMartiniqueMauritaniaMauritiusMayotteMexicoMicronesiaMoldovaMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarN. Mariana Isls.NamibiaNauruNepalNetherlandsNetherlands AntillesNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorthern IrelandNorwayOmanPakistanPalauPalestinian Territory, OccupiedPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalPuerto RicoQatarReunionRomaniaRussian FederationRwandaSaint Kitts and NevisSaint LuciaSamoaSan MarinoSao Tome/PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSlovak RepublicSloveniaSolomon IslandsSomaliaSouth AfricaSpainSri LankaSt. HelenaSt. Pierre and MiquelonSt. Vincent and GrenadinesSudanSurinameSvalbard/Jan Mayen Isls.SwazilandSwedenSwitzerlandSyriaTaiwanTajikistanTanzaniaThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks/Caicos Isls.TuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUS Minor Outlying Is.UruguayUzbekistanVanuatuVatican CityVenezuelaViet NamVirgin Islands (British)Virgin Islands (U.S.)Wallis/Futuna Isls.Western SaharaYemenZambiaZimbabweState or Province*--Please Select--Other - not US or CAAlaskaAlabamaArkansasArizonaCaliforniaColoradoConnecticutD.C.DelawareFloridaMicronesiaGeorgiaHawaiiIowaIdahoIllinoisIndianaKansasKentuckyLouisianaMassachusettsMarylandMaineMichiganMinnesotaMissouriMarianasMississippiMontanaNorth CarolinaNorth DakotaNebraskaNew HampshireNew JerseyNew MexicoNevadaNew YorkOhioOklahomaOregonPennsylvaniaRhode IslandSouth CarolinaSouth DakotaTennesseeTexasUtahVirginiaVermontWashingtonWisconsinWest VirginiaWyomingAlbertaManitobaBritish ColumbiaNew BrunswickNewfoundland and LabradorNova ScotiaNorthwest TerritoriesNunavutOntarioPrince Edward IslandQuebecSaskatchewanYukon TerritoryCompany*Choose your industry* --Please Select--Aerospace-DefenseAgricultureAirlinesAirportsAutomotiveBuilding automation-HVACBuilding MaterialsChemical-PetrochemicalEngineering-Consulting FirmEnvironmental and Air QualityFood & BeverageInstrumentation & ControlsLife ScienceLiquid ConcentrationLogisticsMaritimeMetal manufacturing-processingMeteorologyMiningMuseums and ArchivesOther Industrial ManufacturingPlastics ManufacturingPower & EnergyPulp and PaperRenewable EnergyResearch organization (or University)Roads & RailSemiconductor-ElectronicsTimber and Wood productsWind EnergyTitleBusiness Phone*I authorize Vaisala to send me information about relevant products and services. See our Privacy Policy for more details. You can modify your preference settings or unsubscribe at any time here