Protein concentration and filtration

Protein production require adequate monitoring and control for maximizing yield and to obtain the desired level of purity. Downstream operations such as diafiltration, desalting and buffer exchange e.g. by ultrafiltration are common steps used for concentration and purification that require efficient concentration control as they are critical for final yield and quality.

Download our application note and learn how, by utilizing real-time concentration measurements by Vaisala Polaris™ Refractometer, pharmaceutical manufacturers can:

• Monitor in real-time protein and buffer concentration during concentration, desalting or buffer exchange
• Ensure correct protein buffer concentrations
• Maximize product yield in each step and guarantee purity of proteins
• Adjust concentration levels after ultrafiltration

The application note explains in more detail the benefits of using refractive index in biopharmaceuticals manufacturing and why refractometer is ideal for protein concentration and filtration. The note also includes recommended installation points for best performance.

Download the application note (PDF) by filling the form.

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