Incubator Measurement and Monitoring

Monitoring, Validation and Mapping in Incubators and Test Chambers

One of the most important devices in producing and researching biopharmaceuticals is the CO2 incubator, which are used for cell culture processes in many applications, including antibody production, tissue engineering, viral vaccine research, reproductive technologies, cell and gene therapies, and toxicity studies. To be effective, incubators must mimic the environmental conditions of cells in a living body (in vivo) to enable successful cell growth in media with the chamber (in vitro). Culturing cells requires not only ideal conditions in the media used, but also in the incubator chamber.

Accurate measurements mean repeatable processes

For carbon dioxide within incubators, the GMP251 CO2 probe is an ideal solution. The probe is based on Vaisala’s CARBOCAP® technology that ensures measurement stability. The CARBOCAP sensor features a new type of infrared (IR) light source, instead of the traditional incandescent light. This advance significantly extends the expected lifetime of the probe. The GMP251 probe also calculates temperature and pressure compensations, important with any gas measurement, and the sensor head is heated to prevent condensation.

Wireless monitoring simplify installations

In the latest adaptation of GMP251 probe technology, the probe is connected to a wireless data logger to provide easier installation and send real-time and historical data to Vaisala’s viewLinc Continuous monitoring system. As the software component of this system, viewLinc provides local and remote alarming, real-time trend data, and reports for compliance with regulations. viewLinc monitors multiple parameters, including temperature, relative humidity, CO2, differential pressure, level, door switches, etc. and sends alarms via text, email, or phone dial-out.

The RFL100 CO2 data logger uses Vaisala’s proprietary wireless technology VaiNet to achieve wired-equivalent connectivity and superior signal strength to 100 m (330 ft.). The  RFL100 carbon dioxide data logger can measure CO2 %, CO2 % with temperature, or CO2 % with temperature and humidity. Designed for incubators, the RFL100 includes probe-mounting options that allow for secure and flexible placement within an incubator. Optional heat-resistant cables simplify heat sterilization processes because only the probe needs to be removed. Easy removal of probes also allows for easy calibration.

What Makes Vaisala’s CO2 Sensors Unique?

Vaisala uses a single-beam and dual-wavelength NDIR (Non-dispersive infrared) technology for measuring CO2. The patented CARBOCAP® technology is used in all its CO2 sensors. This technology incorporates a unique tunable band pass filter that was developed by Vaisala and is manufactured in our own state-of-the-art cleanroom. 

Learn about CARBOCAP technology

Incubator Measurement and Monitoring Related Products

Indigo520 with probe

Indigo500 Series Transmitters

The Vaisala Indigo500 series transmitters are host devices for Vaisala Indigo-compatible, stand-alone smart probes. The Indigo500 series include multi-functional Indigo520 transmitter and Indigo510 transmitter with basic features.
The Vaisala CARBOCAP® Carbon Dioxide Probe GMP251 is an intelligent, stand-alone, %-level probe for stable and accurate CO2 measurements.

CO₂ Probe GMP251

The Vaisala CARBOCAP® Carbon Dioxide Probe GMP251 is an intelligent, stand-alone, %-level probe for measuring CO2 in life science incubators, cold storage facilities, fruit and vegetable transportation, and in all demanding applications where stable and accurate percentage-level CO2 measurements are needed.
The Vaisala CARBOCAP® Carbon Dioxide Probe GMP231 is a CO2 meter for incubator manufacturers needing reliable incubator CO2 sensor.

CO₂ Probe GMP231

The Vaisala CARBOCAP ® Carbon Dioxide Probe GMP231 is designed to provide incubator manufacturers with accurate and reliable carbon dioxide measurements and sterilization durability at high temperatures, up to 180 °C

viewLinc Monitoring, Alarming and Reporting Software

The viewLinc Enterprise Server software monitors temperature, relative humidity, CO 2 , differential pressure, level, door switches, and more, offering low cost of ownership due to easy connectivity to your existing network, remote access, and scalability up to thousands of monitored locations.
VDL200 Power Over Ethernet Data Logger

VDL200 Data Logger

The VDL200 data logger integrates Vaisala's advanced sensor technology with the viewLinc Continuous Monitoring System software.
The Vaisala HUMICAP® Humidity Module HMM100 is an open frame module for integration into environmental chambers.

Humidity Module HMM100

The Vaisala HUMICAP® Humidity Module HMM100 is an open frame module for integration into environmental chambers. The modules provide a single analog output channel for relative humidity (RH) or dew point (Td).

How to Install an RFL100 series data logger

Related resources

Video

On-site calibration of CO2 in a working incubator

Vaisala’s Application engineer Nevon Mansour demonstrates how to do on-site calibration of CO2 in a working incubator.

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Ensuring GxP Compliance with Monitoring System Transparency

In viewLinc Cloud, we have added the functions that help with managing updates while ensuring the software remains in a validated, GxP-compliant state. 

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Customer case

Danish pharmacies invest in hi-tech environmental monitoring system

The construction of a new building prompted one of Denmark’s largest pharmacy businesses to invest in Vaisala’s viewLinc Continuous Monitoring System (CMS) to protect the production, handling and storage of medicines.

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Vaisala’s newest data logger provides secure environmental monitoring for GxP compliance

The VDL200 data logger extends the Ethernet connectivity capabilities of the Vaisala viewLinc Continuous Monitoring system with secure, multi-parameter measurement.

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Webinar

CO2 measurements in life science incubators

To make sure that your incubator works properly and maintains the desired CO2 concentration, CO2 must be measured and controlled with great precision. How can this be achieved? Our three experts, Juhani, Maria and Piritta, discuss CO2 measurements in cell-culture incubators. 

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Application note

Wireless CO2 monitoring in incubators

With advances in wireless technologies like the RFL100, and development of smart probes like the GMP251, installation, deployment, calibration, data integrity, and compliance with GxP regulations can provide researchers and manufacturers with a competitive advantage.

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Repository

Articles on GxP standards & regulations

Visit our repository of articles, white papers, application notes and eBooks...

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