Vaccine production Viral vaccines are used globally to protect humans against infections. Vaccines are made by first growing a virus in an egg-based or cell-based process. The virus is then inactivated or attenuated, concentrated and purified, before it is finally blended with other components for making the final vaccine formulation. Purification is one of the most important operations, as it removes impurities originating from host cells or culture media and ensures the safety and efficiency of the final product. It is also one of the costliest steps in manufacturing. Sucrose gradient centrifugation is widely used for the purification and concentration of viruses in large scale production. Vaccine production Download our application note and learn how, by utilizing real-time concentration measurements by Vaisala Polaris™ Refractometer, pharmaceutical manufacturers can: Reliably isolate virus fractions in the purification phase Ensure high-quality vaccines Increase yield and productivity The Polaris refractometer is a valuable PAT tool during research and development phase. The application note explains the benefits of using refractive index in downstream operations of vaccine production. The note also includes recommended installation points for best performance. Download the application note (PDF) by filling the form. Watch our webinar on Fast and efficient viral vaccines purification by sucrose density gradient Discover all applications in Pharmaceutical drug manufacturing and biotechnology processes. 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Viral vaccines are used globally to protect humans against infections. Vaccines are made by first growing a virus in an egg-based or cell-based process. The virus is then inactivated or attenuated, concentrated and purified, before it is finally blended with other components for making the final vaccine formulation. Purification is one of the most important operations, as it removes impurities originating from host cells or culture media and ensures the safety and efficiency of the final product. It is also one of the costliest steps in manufacturing. Sucrose gradient centrifugation is widely used for the purification and concentration of viruses in large scale production. Vaccine production Download our application note and learn how, by utilizing real-time concentration measurements by Vaisala Polaris™ Refractometer, pharmaceutical manufacturers can: Reliably isolate virus fractions in the purification phase Ensure high-quality vaccines Increase yield and productivity The Polaris refractometer is a valuable PAT tool during research and development phase. The application note explains the benefits of using refractive index in downstream operations of vaccine production. The note also includes recommended installation points for best performance. Download the application note (PDF) by filling the form. Watch our webinar on Fast and efficient viral vaccines purification by sucrose density gradient Discover all applications in Pharmaceutical drug manufacturing and biotechnology processes. Image Email Address*First Name*Last Name*My application (process/ liquid)Country*--Please Select--United StatesUnited KingdomCanadaChinaIndiaJapanAustraliaBrazilFranceGermanyFinland--------------AfghanistanÅland IslandsAlbaniaAlgeriaAmerican SamoaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBoliviaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBrit/Indian Ocean Terr.Brunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Dem. Republic OfCook IslandsCosta RicaCôte D'IvoireCroatiaCubaCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland IslandsFaroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern Terr.GabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuamGuatemalaGuineaGuinea-BissauGuyanaHaitiHeard/McDonald Isls.HondurasHong KongHungaryIcelandIndiaIndonesiaIranIraqIrelandIsraelItalyJamaicaJapanJordanKazakhstanKenyaKiribatiKorea (North)Korea (South)KuwaitKyrgyzstanLaosLatviaLebanonLesothoLiberiaLibyaLiechtensteinLithuaniaLuxembourgMacauMacedoniaMadagascarMalawiMalaysiaMaldivesMaliMaltaMarshall IslandsMartiniqueMauritaniaMauritiusMayotteMexicoMicronesiaMoldovaMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarN. Mariana Isls.NamibiaNauruNepalNetherlandsNetherlands AntillesNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorthern IrelandNorwayOmanPakistanPalauPalestinian Territory, OccupiedPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalPuerto RicoQatarReunionRomaniaRussian FederationRwandaSaint Kitts and NevisSaint LuciaSamoaSan MarinoSao Tome/PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSlovak RepublicSloveniaSolomon IslandsSomaliaSouth AfricaSpainSri LankaSt. HelenaSt. Pierre and MiquelonSt. Vincent and GrenadinesSudanSurinameSvalbard/Jan Mayen Isls.SwazilandSwedenSwitzerlandSyriaTaiwanTajikistanTanzaniaThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks/Caicos Isls.TuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUS Minor Outlying Is.UruguayUzbekistanVanuatuVatican CityVenezuelaViet NamVirgin Islands (British)Virgin Islands (U.S.)Wallis/Futuna Isls.Western SaharaYemenZambiaZimbabweState or Province*--Please Select--Other - not US or CAAlaskaAlabamaArkansasArizonaCaliforniaColoradoConnecticutD.C.DelawareFloridaMicronesiaGeorgiaHawaiiIowaIdahoIllinoisIndianaKansasKentuckyLouisianaMassachusettsMarylandMaineMichiganMinnesotaMissouriMarianasMississippiMontanaNorth CarolinaNorth DakotaNebraskaNew HampshireNew JerseyNew MexicoNevadaNew YorkOhioOklahomaOregonPennsylvaniaRhode IslandSouth CarolinaSouth DakotaTennesseeTexasUtahVirginiaVermontWashingtonWisconsinWest VirginiaWyomingAlbertaManitobaBritish ColumbiaNew BrunswickNewfoundland and LabradorNova ScotiaNorthwest TerritoriesNunavutOntarioPrince Edward IslandQuebecSaskatchewanYukon TerritoryCompany*Choose your industry* --Please Select--Aerospace-DefenseAgricultureAirlinesAirportsAutomotiveBuilding automation-HVACBuilding MaterialsChemical-PetrochemicalEngineering-Consulting FirmEnvironmental and Air QualityFood & BeverageInstrumentation & ControlsLife ScienceLiquid ConcentrationLogisticsMaritimeMetal manufacturing-processingMeteorologyMiningMuseums and ArchivesOther Industrial ManufacturingPlastics ManufacturingPower & EnergyPulp and PaperRenewable EnergyResearch organization (or University)Roads & RailSemiconductor-ElectronicsTimber and Wood productsWind EnergyTitleBusiness Phone*I authorize Vaisala to send me information about relevant products and services. See our Privacy Policy for more details. You can modify your preference settings or unsubscribe at any time here